methylprednisolone + lidocaine

methylprednisolone + lidocaine is a combination drug consisting of a synthetic corticosteroid and a local anesthetic, used primarily for the management of pain and inflammation in osteoarthritis. In the context of a Mayo Clinic phase 4 clinical trial, this combination is administered via intra-articular injection to treat hand and wrist osteoarthritis. Methylprednisolone acts as a glucocorticoid receptor agonist, exerting potent anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines and mediators. Lidocaine provides rapid, short-term analgesia by acting as a sodium channel antagonist, blocking the conduction of nerve impulses. This treatment is a standard clinical approach for symptomatic relief of joint pain and swelling, though it does not alter the underlying disease progression.

Brand names

Depo-Medrol with Lidocaine

Other names

Corticosteroid injectionmethylprednisolone/lidocaineCSI