Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
methylprednisolone + methotrexate
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular, Subcutaneous
01
Overview
The combination of methylprednisolone and methotrexate is used for its synergistic anti-inflammatory and immunosuppressive effects. Methylprednisolone is a synthetic glucocorticoid that suppresses inflammation by inhibiting the migration of polymorphonuclear leukocytes, reversing increased capillary permeability, and suppressing the immune system. Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, thereby interfering with DNA synthesis, cell replication, and immune function. Together, this combination has shown improved efficacy in conditions such as bullous pemphigoid (enabling rapid glucocorticoid tapering) and in experimental models of spinal cord injury (enhancing neuroprotection by reducing inflammation and apoptosis)[1][3].
- Other names
- MP + MTXmethylprednisolone and methotrexate
02
Targets
GR (Glucocorticoid receptor)DHFR (Dihydrofolate reductase)
Beyond the preview
Go deeper on methylprednisolone + methotrexate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on methylprednisolone + methotrexate.