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Drug intelligence / Profile preview
methylprednisolone + sofosbuvir + velpatasvir
- Development stage
- Unknown
- Lead developer
- Gilead Sciences
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Reversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
This is a combination of three drugs:
- Methylprednisolone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It acts by binding to the glucocorticoid receptor, modulating gene expression, and suppressing immune responses.
- Sofosbuvir is a nucleotide analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, essential for viral replication. It prevents HCV from multiplying in the body.
- Velpatasvir is an inhibitor of the HCV NS5A protein, which plays a key role in viral replication and assembly. Sofosbuvir and velpatasvir are direct-acting antivirals used together as a fixed-dose combination for treating chronic hepatitis C infection across all major genotypes.
There are no known approved products or brand names that combine all three agents into one formulation; this appears to be an unbranded or investigational combination.
02
Targets
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