Drug intelligence / Profile preview

methylprednisolone + sofosbuvir + velpatasvir

Development stage
Unknown
Lead developer
Gilead Sciences
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Reversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

This is a combination of three drugs: - **Methylprednisolone** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It acts by binding to the glucocorticoid receptor, modulating gene expression, and suppressing immune responses. - **Sofosbuvir** is a nucleotide analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, essential for viral replication. It prevents HCV from multiplying in the body[1][3][8]. - **Velpatasvir** is an inhibitor of the HCV NS5A protein, which plays a key role in viral replication and assembly[1][6]. Sofosbuvir and velpatasvir are direct-acting antivirals used together as a fixed-dose combination for treating chronic hepatitis C infection across all major genotypes[2][3]. There are no known approved products or brand names that combine all three agents into one formulation; this appears to be an unbranded or investigational combination.

02

Targets

GR (Glucocorticoid receptor)NS5A (Hepatitis C virus nonstructural protein 5A (genotype 1b))NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)

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