metoclopramide + dexamethasone

Metoclopramide + dexamethasone is a combination of two pharmaceutical agents used primarily for the prevention and treatment of nausea and vomiting, especially in settings such as chemotherapy-induced emesis and postoperative nausea and vomiting (PONV). Metoclopramide is a dopamine D2 receptor antagonist with additional activity at serotonin 5-HT3 receptors (antagonist) and 5-HT4 receptors (agonist), leading to antiemetic effects via inhibition of the chemoreceptor trigger zone in the brain, as well as prokinetic effects on gastrointestinal motility. Dexamethasone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory properties; its precise antiemetic mechanism is not fully understood but may involve central inhibition of prostaglandin synthesis or reduction in blood-brain barrier permeability to emetogenic substances. The combination has been shown to be more effective than either drug alone for preventing nausea and vomiting after surgery or chemotherapy[1][2][3][5]. It can be administered intravenously, orally, or rectally depending on clinical context[6].