metoclopramide + ketorolac

A combination medication consisting of metoclopramide and ketorolac used primarily for the treatment of acute migraine headaches in emergency department settings. This combination is sometimes referred to as part of a "migraine cocktail." Metoclopramide is an antiemetic and prokinetic agent that works by blocking dopamine receptors and stimulating gastrointestinal motility. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) with potent analgesic, anti-inflammatory, and antipyretic properties. Research on the combination's effectiveness shows varying results, with some studies in children failing to show improved pain intensity compared to metoclopramide monotherapy.