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metopimazine + prednisolone
- Development stage
- Unknown
- Lead developer
- Neurogastrx
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Metopimazine + prednisolone is a combination antiemetic therapy used primarily for the prevention and treatment of chemotherapy-induced nausea and vomiting. Metopimazine is a phenothiazine antiemetic with antidopaminergic, antihistamine, and anticholinergic properties, while prednisolone is a corticosteroid. This combination has demonstrated superior efficacy compared to single-agent treatments, particularly in moderately emetogenic chemotherapy regimens. The combination is often used with a serotonin (5-HT3) receptor antagonist such as ondansetron or granisetron for enhanced antiemetic effect.
02
Targets
HRH1 (Histamine H1 Receptor)GR (Glucocorticoid receptor)ADRA1A (α1A)mAChR (Muscarinic acetylcholine receptors)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)
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