metoprolol succinate + felodipine

Metoprolol succinate + felodipine is a fixed-dose oral combination of two antihypertensive agents used to treat high blood pressure. Metoprolol succinate is a beta1-selective adrenergic receptor blocker (beta-blocker) that reduces heart rate and cardiac output by antagonizing beta1-adrenoceptors in the heart, leading to decreased blood pressure and reduced myocardial oxygen demand[5][8]. Felodipine is a long-acting dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, resulting in vasodilation and decreased peripheral resistance[6]. The combination provides additive antihypertensive effects by targeting both cardiac output and vascular tone, offering improved blood pressure control compared to either agent alone without compromising tolerability[1][3].

Brand names

Logimax

Other names

felodipine/metoprololfelodipine and metoprololfelodipine-metoprolol combination tablet