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metoprolol succinate extended-release (Dr. Reddy's)
- Development stage
- Unknown
- Lead developer
- Dr. Reddy's Laboratories
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Metoprolol succinate is a cardioselective beta-1 adrenergic receptor blocker used primarily for the treatment of hypertension, angina pectoris, and stable heart failure. As a small molecule antagonist, it selectively binds to beta-1 receptors in cardiac tissue, leading to a reduction in heart rate, cardiac contractility, and systemic blood pressure. The specific entity generic a-University of Florida-hypertension refers to the generic metoprolol extended-release formulation manufactured by Dr. Reddy's Laboratories, which was evaluated in a University of Florida clinical trial (NCT01830309) comparing its pharmacokinetic and pharmacodynamic profiles against the brand-name drug Toprol XL. This study aimed to address concerns regarding the bioequivalence and clinical consistency of generic metoprolol ER products in patients with hypertension.
- Other names
- metoprolol succinate ERmetoprolol succinategeneric a-University of Florida-hypertension
02
Targets
ADRB2 (β2)ADRB1 (β1)
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