metronidazole + ciprofloxacin

Metronidazole + ciprofloxacin is a fixed-dose combination of two antibiotics used primarily to treat mixed bacterial infections, especially those involving both aerobic and anaerobic organisms. Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and leading to cell death. Metronidazole is a nitroimidazole antibiotic that disrupts the DNA of anaerobic bacteria and protozoa, resulting in cell death. This combination is commonly prescribed for diarrhea, dysentery, intra-abdominal infections (such as peritonitis or diverticulitis), pelvic inflammatory disease, bone and joint infections, pneumonia with lung abscesses, skin/soft tissue infections, surgical prophylaxis for abdominal procedures, and active Crohn’s disease involving the colon or ileum[1][3][4][6]. The combination targets both aerobic Gram-negative bacteria (ciprofloxacin) and anaerobic pathogens (metronidazole), providing broad-spectrum coverage.

Brand names

Hicipro MTropenor

Other names

ciprofloxacin + metronidazole