Drug intelligence / Profile preview

metronidazole + clotrimazole + chlorhexidine acetate

Development stage
Unknown
Lead developer
West China Second University Hospital
Modality
Small Molecules
Administration
Vaginal
01

Overview

Diazoltec (Shuang Zuo Tai) is a fixed-dose combination vaginal therapy widely used in China for the treatment of mixed vaginal infections, including bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomonal vaginitis. It contains three active ingredients: metronidazole, a nitroimidazole antimicrobial that targets anaerobic bacteria and protozoa by causing DNA strand breakage; clotrimazole, an azole antifungal that inhibits the enzyme lanosterol 14-alpha demethylase to disrupt fungal ergosterol synthesis; and chlorhexidine acetate, a broad-spectrum antiseptic that disrupts microbial cell membranes. The effervescent tablet formulation is designed for vaginal administration, providing rapid dissolution and comprehensive antimicrobial coverage against the diverse pathogens involved in complex vaginal dysbiosis.

Brand names
DiazoltecShuang Zuo Tai
Other names
ShuangzuotaiMetronidazole, Clotrimazole and Chlorhexidine Acetate Effervescent Tablets
02

Targets

NeuraminidaseCYP51A1 (Sterol 14α-demethylase)

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