metronidazole + miconazole

Metronidazole + miconazole is a fixed-dose combination of two small molecule drugs used primarily for the treatment of vaginal and skin infections caused by mixed bacterial and fungal pathogens. Metronidazole is an antibiotic that exerts its effect by damaging the DNA of bacteria and certain protozoa, leading to cell death. Miconazole is an antifungal agent that inhibits the synthesis of ergosterol, a key component in fungal cell membranes, thereby disrupting membrane integrity and inhibiting fungal growth. This combination provides broad-spectrum coverage against both anaerobic bacteria (via metronidazole) and fungi (via miconazole), making it effective for conditions such as bacterial vaginosis with concurrent candidiasis or other mixed infections[1][4][6]. The combination is available in various formulations including vaginal suppositories and creams.

Brand names

Metromicon-NeoKlion-D 100Klion-D100Klion-D-100Neo-Penotran

Other names

metronidazole and miconazole nitrate vaginal suppository