Drug intelligence / Profile preview

mezagitamab + lenalidomide + dexamethasone

Development stage
Unknown
Lead developer
Takeda
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Subcutaneous, Oral
01

Overview

This is a combination regimen composed of mezagitamab, lenalidomide, and dexamethasone: - **Mezagitamab** is a monoclonal antibody targeting CD38, designed for the treatment of multiple myeloma and other hematological malignancies through immune-mediated destruction of CD38-expressing tumor cells[5]. - **Lenalidomide** is an immunomodulatory small molecule acting on multiple myeloma cells, approved for use in combination with dexamethasone in various lines of therapy, primarily through modulation of the cereblon E3 ubiquitin ligase complex and influencing immune response[1][2][4]. - **Dexamethasone** is a synthetic glucocorticoid corticosteroid used as an anti-inflammatory and immunosuppressant, commonly given orally in myeloma regimens. This combination is in investigation for relapsed/refractory multiple myeloma[5].

Brand names
Revlimid (lenalidomide)Decadron (dexamethasone)
02

Targets

CRBN (Cereblon)CD38 (Cluster of Differentiation 38)GR (Glucocorticoid receptor)

Beyond the preview

Go deeper on mezagitamab + lenalidomide + dexamethasone.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on mezagitamab + lenalidomide + dexamethasone.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call