mGIP(3-30)

mGIP(3-30) is a truncated peptide derivative of the mouse glucose-dependent insulinotropic polypeptide (GIP). It acts as a high-affinity antagonist of the GIP receptor (GIPR) in mice, effectively inhibiting the physiological actions of endogenous GIP. Unlike full-length or agonist forms of GIP, mGIP(3-30) does not stimulate insulin secretion but instead blocks the insulinotropic and glucose-lowering effects mediated by native GIP peptides. This makes it a valuable tool for studying incretin physiology and pathophysiology in rodent models, particularly for research into metabolic diseases such as obesity and diabetes[3][7]. The peptide is used primarily in preclinical research settings to investigate the role of GIP signaling in metabolic regulation.

Other names

mouse GIP(3-30)mouse GIP(3-30)NH2