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microcrystalline cellulose + methylcellulose

Development stage: Unknown
Lead developer: Rachel Holden
Modality: Small Molecules
Administration: Oral

Overview

Microcrystalline cellulose and methylcellulose are pharmaceutical excipients used in combination as a placebo in the iPACK-HD (Inhibit Progression of Coronary Artery Calcification With Vitamin K in HemoDialysis Patients) study. Led by Dr. Rachel Holden at Queen's University, this Phase 2 clinical trial evaluated the efficacy of high-dose vitamin K1 (phylloquinone) in reducing the progression of coronary artery calcification in patients receiving hemodialysis. The microcrystalline methylcellulose formulation was designed to be identical in appearance to the 10mg vitamin K1 tablets and was administered orally three times weekly over a 12-month period to the control group. As a placebo, the substance is intended to be biologically inert and does not possess a therapeutic mechanism of action for cardiovascular or renal diseases.

Other names: Microcrystalline Methylcellulose

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