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midazolam + ketamine + sevoflurane
- Development stage
- Phase 2
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular, Inhalation
01
Overview
This is a combination of three anesthetic/sedative agents used for induction and maintenance of anesthesia or sedation, particularly in pediatric and veterinary settings. Midazolam is a short-acting benzodiazepine providing anxiolysis, amnesia, and sedation; ketamine is an NMDA receptor antagonist providing analgesia and dissociative anesthesia; sevoflurane is an inhaled halogenated ether used for general anesthesia with rapid onset and recovery. The combination leverages the synergistic effects of these drugs to provide balanced anesthesia with reduced side effects compared to single-agent use[2][6][8].
- Other names
- midazolam, ketamine and sevofluranemidazolam/ketamine/sevoflurane
02
Targets
GABA-B (Gamma-aminobutyric acid receptor type B)GLRA1 (Glycine receptor subunit Alpha-1)NMDAR (Glutamate receptor ionotropic, NMDA)
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