Drug intelligence / Profile preview

midazolam + sufentanil + cisatracurium

Development stage
Unknown
Lead developer
Shaanxi Provincial People's Hospital
Modality
Small Molecules
Administration
Intravenous
01

Overview

midazolam + sufentanil + cisatracurium is a pharmacological combination used for the induction of anesthesia, specifically as a standardized protocol in clinical research at Shaanxi Provincial People's Hospital. The regimen consists of midazolam, a benzodiazepine that acts as a positive allosteric modulator of the GABA-A receptor to provide sedation and amnesia; sufentanil, a potent synthetic opioid analgesic that targets the mu-opioid receptor; and cisatracurium, a non-depolarizing neuromuscular blocking agent that antagonizes nicotinic acetylcholine receptors at the neuromuscular junction. This combination is designed to facilitate a stable transition to a surgical plane of anesthesia, particularly in elderly patients undergoing procedures such as hysteroscopy.

Other names
Anesthesia induction protocol (Shaanxi Provincial People's Hospital)
02

Targets

Nicotinic Acetylcholine ReceptorBZD site (GABA-A receptor benzodiazepine site)MOR (Mu opioid receptor)

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