midazolam + sufentanil + propofol + rocuronium

This combination anesthetic regimen is used for inducing and maintaining general anesthesia in patients with difficult airways undergoing fiberoptic endotracheal intubation. The regimen consists of **midazolam** (a benzodiazepine for sedation and amnesia), **sufentanil** (a potent opioid analgesic), **propofol** (an intravenous sedative-hypnotic), and **rocuronium** (a non-depolarizing neuromuscular blocking agent). In clinical studies conducted by Peking University (such as NCT04841408), this specific combination is administered intravenously to achieve a deep state of anesthesia (typically targeted to a Bispectral Index of less than 60) to facilitate safe airway management. It is often evaluated in conjunction with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE), which provides continuous oxygenation and extends the safe apnea time during the intubation procedure.

Other names

THRIVE anesthesia regimenGeneral anesthesia for difficult airway intubation