Drug intelligence / Profile preview

milvexian + atorvastatin

Development stage
Unknown
Lead developer
Bristol Myers Squibb
Modality
Small Molecules
Administration
Oral
01

Overview

Milvexian + atorvastatin is a combination of two small-molecule drugs, where **milvexian** is an oral, selective inhibitor of Factor XIa (a protein involved in the coagulation cascade), investigated to reduce the risk of thrombotic events without increasing bleeding risk, and **atorvastatin** is an HMG-CoA reductase inhibitor ("statin") widely used to lower cholesterol and prevent cardiovascular events. This combination is being specifically studied to assess whether co-administration leads to pharmacokinetic or clinically significant drug-drug interactions, and not as a fixed-dose clinical product. Milvexian is under development for various cardiovascular indications, while atorvastatin is an established, approved therapy for hyperlipidemia and cardiovascular risk reduction[1][2][3][4][6].

02

Targets

Factor XIaHMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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