minocycline + hydroxychloroquine

A combination of minocycline and hydroxychloroquine that has shown unexpected additive effects in treating various conditions. Minocycline is an antibiotic in the tetracycline family with anti-inflammatory properties, while hydroxychloroquine is an antimalarial drug commonly used for autoimmune conditions. The combination has demonstrated synergistic effects in experimental models of multiple sclerosis, with potential applications in rheumatoid arthritis and COVID-19. The mechanism involves combined inhibition of microglia, modulation of T-cell and B-cell proliferation, iron neurotoxicity reduction, and anticytokine effects.