miR-125b* mimic

miR-125b* mimic is an experimental **microRNA replacement therapy** consisting of a synthetic mimic of microRNA-125b-2-3p, the passenger-strand miRNA commonly referred to as miR-125b*. It has been studied preclinically as an intravenously delivered RNA therapeutic for **acute myocardial infarction and ischemia-reperfusion injury**, where increasing myocardial miR-125b* levels reduced infarct size in mouse models. The proposed mechanism is restoration or augmentation of a cardioprotective endogenous miRNA network that downregulates multiple injury-related transcripts rather than acting through a single receptor target. Published work links the program to investigators at **Pharmahungary**, **Semmelweis University**, and the **University of Szeged**; no evidence of commercial approval, branded product status, or late-stage clinical development was identified.

Other names

microRNA-125b-2-3p mimicmicroRNA125b-2-3p mimicmicroRNA 125b-2-3p mimicmiR-125b-2-3p mimicmiR125b-2-3p mimicmiR 125b-2-3p mimicmiR-125b star mimicmiR125b star mimicmiR 125b star mimic