mirtazapine + dexamethasone

Mirtazapine + dexamethasone is a combination of two pharmaceutical agents used primarily for the prevention and management of nausea and vomiting, particularly in settings such as chemotherapy-induced or postoperative nausea. Mirtazapine is a tetracyclic antidepressant that acts as an antagonist at several serotonin (5-HT2A, 5-HT2C, 5-HT3) and histamine H1 receptors, which contributes to its antiemetic properties[1][4][6]. Dexamethasone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive effects; it also has established efficacy in reducing nausea associated with chemotherapy or surgery. The combination has been shown to be more effective than dexamethasone alone for preventing postoperative or chemotherapy-induced nausea and vomiting[1][4]. However, the use of this combination may increase the risk of additive central nervous system depression[3].