Drug intelligence / Profile preview

misoprostol + Foley catheter

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Vaginal
01

Overview

The combination of misoprostol and a Foley catheter is a dual-modality intervention used for the induction of labor in term pregnancies, particularly in cases with an unfavorable cervix (low Bishop score). Misoprostol is a synthetic prostaglandin E1 (PGE1) analog that promotes cervical ripening and stimulates uterine contractions by acting as an agonist at prostaglandin receptors. The Foley catheter serves as a mechanical dilator; when inserted into the cervix and inflated, it exerts direct pressure on the internal os, physically opening the cervical canal and stimulating the endogenous release of prostaglandins. This specific regimen has been the subject of clinical research at Zagazig University to evaluate the efficacy and safety of sequential versus concurrent administration of these two methods to optimize labor induction outcomes.

Other names
vaginal misoprostol plus Foley cathetermisoprostol and Foley catheter
02

Targets

PTGER3 (Prostaglandin E2 receptor EP3 subtype)PTGER2 (Prostaglandin E2 receptor EP2)PTGER4 (Prostaglandin E2 receptor EP4 subtype)PTGER1 (Prostaglandin E Receptor 1)

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