Drug intelligence / Profile preview

mitiglinide + voglibose

Development stage
Unknown
Lead developer
Kissei Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

**GLUBES** is an oral fixed-dose antidiabetic combination of mitiglinide calcium hydrate and voglibose, developed and marketed in Japan by Kissei for type 2 diabetes mellitus when concomitant treatment with both components is appropriate. Each tablet contains mitiglinide calcium hydrate 10 mg and voglibose 0.2 mg. Mitiglinide is a rapid, short-acting insulin secretagogue that promotes early postprandial insulin release, while voglibose inhibits intestinal alpha-glucosidases to delay carbohydrate digestion and absorption, thereby reducing postprandial glucose excursions. GLUBES was launched as a conventional tablet in July 2011; an orally disintegrating tablet formulation was launched in June 2019. ([kissei.co.jp](https://www.kissei.co.jp/e_contents/news/2011/20110721-668.html))

Brand names
GLUBESGLUBES Combination OD TabletGLUBES Combination Tablet
Other names
mitiglinide calcium hydrate + voglibosemitiglinide calcium hydrate/voglibose
02

Targets

ATP-sensitive potassium channel complex (Kir6.2/SUR1)Sucrase-Isomaltase

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