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mitoxantrone + raltitrexed + anlotinib + benmelstobart
- Development stage
- Phase 2
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination therapy is an investigational antineoplastic regimen consisting of four distinct agents: mitoxantrone, raltitrexed, anlotinib, and benmelstobart (TQB2450). Mitoxantrone is a type II topoisomerase inhibitor that induces DNA damage, while raltitrexed is a specific thymidylate synthase inhibitor that disrupts DNA synthesis. Anlotinib is a multi-target tyrosine kinase inhibitor (TKI) that primarily inhibits angiogenesis by targeting VEGFR, FGFR, PDGFR, and c-Kit. Benmelstobart is a humanized monoclonal antibody targeting programmed cell death ligand 1 (PD-L1), designed to restore anti-tumor immune responses. The combination is primarily being evaluated for the treatment of extensive-stage small cell lung cancer (ES-SCLC) and other refractory solid tumors, aiming to leverage the synergistic effects of cytotoxic chemotherapy, anti-angiogenesis, and immune checkpoint blockade.
- Brand names
- Focus V
- Other names
- mitoxantrone + raltitrexed + anlotinib + TQB2450mitoxantrone + raltitrexed + anlotinib + benmelstobartBenmelstobart + Anlotinib + Mitoxantrone + Raltitrexed
02
Targets
CD80 (T-lymphocyte activation antigen CD80)TOP2A (DNA topoisomerase II)CD274 (Programmed cell death protein 1 ligand 1)PDGFRA (Platelet-derived growth factor receptor alpha)PKC (Protein kinase C family)RET (Rearranged during transfection receptor tyrosine kinase)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR (FGFR family)
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