mixed amphetamine salts (Takeda, 043683)

Mixed amphetamine salts (MAS) is a central nervous system stimulant medication composed of a specific 3:1 ratio of dextroamphetamine and levoamphetamine salts. The standard formulation includes four salts: amphetamine aspartate monohydrate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate. It functions primarily as a releasing agent and reuptake inhibitor of the monoamine neurotransmitters dopamine and norepinephrine. By targeting the dopamine transporter (DAT) and norepinephrine transporter (NET), as well as acting as an agonist at the trace amine-associated receptor 1 (TAAR1), it increases synaptic concentrations of these neurotransmitters, thereby modulating reward circuitry and executive function. While widely approved for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy, it has been investigated by institutions such as the New York State Psychiatric Institute as a potential pharmacotherapy for cocaine dependence, particularly in patients with comorbid ADHD, to help reduce drug-seeking behavior and improve treatment retention.

Brand names

Adderall XRAdderallMydayisAdzenys XR-ODTDyanavel XR

Other names

MASMAS-ERmixed salts of a single-entity amphetamine productamphetamine mixed salts