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MK-0472 + MK-1084
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**MK-0472 + MK-1084** is a combination of two investigational small molecule drugs being evaluated for the treatment of advanced or metastatic solid tumors. MK-0472 is under investigation as both monotherapy and in combination therapies; MK-1084 is a covalent inhibitor specifically targeting the KRAS G12C mutation—a common mutation in several solid tumors such as colorectal cancer and non-small cell lung cancer. The dual agent regimen is designed to tackle oncogenic driver mutations and potentially enhance antitumor activity by acting on distinct, complementary pathways involved in tumor growth and survival. Both agents are being studied in phase 1 trials to assess safety, tolerability, and preliminary efficacy, primarily in patients with advanced solid tumors and documented KRAS G12C mutations[4][5].
- Other names
- MK-0472MK0472MK 0472MK-1084MK1084MK 1084
02
Targets
KRASG12C (Kirsten rat sarcoma viral oncogene homolog G12C)
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