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MLN2480 + paclitaxel
- Development stage
- Unknown
- Lead developer
- Millennium Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
**MLN2480 + paclitaxel** is an investigational combination therapy consisting of MLN2480 (also known as TAK-580), a small molecule pan-RAF inhibitor (targeting ARAF, BRAF, and CRAF kinases), with paclitaxel, a microtubule stabilizer widely used as a chemotherapeutic. MLN2480 inhibits RAF kinases, thereby blocking the MAPK/ERK signaling pathway that is frequently upregulated in cancer. Paclitaxel disrupts cell division by stabilizing microtubules and promoting apoptosis. This combination is being evaluated in adult patients with advanced nonhematologic malignancies, particularly those who have failed standard therapies.
- Other names
- MLN2480MLN-2480MLN 2480TAK-580TAK580TAK 580paclitaxel
02
Targets
TUBB (Tubulin (alpha and beta subunits))RAF1 (c-Raf-1 (Y340D/Y341D))BRAF (B-Raf proto-oncogene, serine/threonine kinase)ARAF (Proto-oncogene serine/threonine-protein kinase A-Raf)
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