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modified Chen's Tang Shen Fang
- Development stage
- Preclinical
- Administration
- Oral
01
Overview
Modified Chen's Tang Shen Fang is a traditional Chinese medicine (TCM) herbal formula, likely based on or derived from the classic "Tangshen Formula" (TSF), which itself is used for diabetic nephropathy and related kidney disorders. The original TSF has demonstrated effects in reducing proteinuria, improving renal function, and modulating lipid metabolism in diabetic kidney disease. Mechanistically, TSF acts by promoting cholesterol efflux via upregulation of peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), Liver X receptors (LXR), and ATP-binding cassette subfamily A member 1 (ABCA1). Modified versions of such formulas typically involve adjustments to the herbal composition to target specific patient needs or syndromes according to TCM principles[3]. The precise composition of "modified Chen's Tang Shen Fang" is not specified in available sources but would be expected to include herbs aimed at nourishing Yin, tonifying Qi, regulating blood circulation, and supporting kidney function.
- Other names
- modified Chen's Tang Shen Fang
02
Targets
PPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)ABCA1 (ATP-binding cassette transporter A1)NR1H3 (Liver X receptor beta)
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