mometasone + azelaic acid

Mometasone + azelaic acid is a topical dermatologic combination that pairs mometasone, a synthetic glucocorticoid corticosteroid, with azelaic acid, a dicarboxylic acid with antimicrobial, keratolytic, depigmenting, and anti-inflammatory properties. Mometasone furoate acts via high-affinity activation of the glucocorticoid receptor to suppress pro‑inflammatory gene transcription and reduce cytokine production, vasodilation, and leukocyte recruitment in the skin, providing potent anti‑inflammatory and antipruritic effects in steroid‑responsive dermatoses.[4][9][12][16] Azelaic acid exerts multiple actions including inhibition of mitochondrial oxidoreductase and 5‑α‑reductase, reduction of reactive oxygen species, antibacterial activity against Cutibacterium acnes and Staphylococcus epidermidis, normalization of keratinization, and competitive inhibition of tyrosinase to reduce melanogenesis, which underlies its efficacy in acne, rosacea, and hyperpigmentation disorders such as melasma.[6][8][18] In combination, these agents are expected to provide complementary anti‑inflammatory and pigment‑modulating activity for inflammatory and pigmentary skin conditions, although this specific fixed combination is not widely standardized or separately characterized in major regulatory or reference databases.