Drug intelligence / Profile preview

mometasone furoate + levocetirizine

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intranasal, Oral
01

Overview

This is a fixed-dose combination of two active pharmaceutical ingredients, mometasone furoate and levocetirizine. Mometasone furoate is a synthetic corticosteroid with potent anti-inflammatory properties, primarily used as a nasal spray to treat symptoms of allergic rhinitis by reducing inflammation in the nasal passages. Levocetirizine is a second-generation antihistamine that acts as an antagonist at the histamine H1 receptor, effectively reducing symptoms such as sneezing, itching, and rhinorrhea associated with allergic conditions. The combination targets both local inflammation (via mometasone) and systemic histaminergic responses (via levocetirizine), providing broader symptom control for moderate to severe persistent allergic rhinitis[1][3][10]. Clinical studies have shown that combining these agents can improve quality of life and symptom scores more than monotherapy with either agent alone[1].

02

Targets

GR (Glucocorticoid receptor)HRH1 (Histamine H1 Receptor)

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