montelukast + prednisolone

Montelukast + prednisolone is a combination of two pharmaceutical agents commonly used in the management of respiratory and inflammatory conditions. Montelukast is a leukotriene receptor antagonist that blocks the action of leukotriene D4 at cysteinyl leukotriene receptor 1, leading to decreased inflammation and relaxation of airway smooth muscle. It is primarily indicated for maintenance treatment of asthma, prevention of exercise-induced bronchoconstriction, and relief from allergic rhinitis[4][6]. Prednisolone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties; it acts by binding to the glucocorticoid receptor, modulating gene expression to suppress pro-inflammatory cytokines. The combination may be used in certain clinical scenarios such as acute asthma exacerbations or severe inflammatory responses where both leukotriene-mediated inflammation and broader immune suppression are desired[3][5]. This combination has been studied for enhanced efficacy in conditions like mycoplasma pneumonia, showing improved modulation of immune response compared to standard therapy alone[3].

Brand names

Prelone

Other names

Montelukast plus prednisoloneMontelukast plus prednisolone-The Hospital for Sick Children-asthma