Drug intelligence / Profile preview

morphine + diazepam + digoxin + amitriptyline

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

This is a **combination drug** consisting of four active pharmaceutical ingredients: **morphine**, **diazepam**, **digoxin**, and **amitriptyline**. Morphine is an opioid analgesic primarily used for severe pain management, acting as an agonist at the mu-opioid receptor to inhibit pain pathways. Diazepam is a benzodiazepine indicated for anxiety, muscle spasms, and seizures; it acts as a positive allosteric modulator at the GABA-A receptor, enhancing inhibitory neurotransmission. Digoxin is a cardiac glycoside used in heart failure and arrhythmias; it inhibits Na/K-ATPase, increasing intracellular calcium and myocardial contractility. Amitriptyline is a tricyclic antidepressant indicated for depression, neuropathic pain, and migraine prophylaxis, working chiefly by inhibiting the presynaptic reuptake of serotonin and norepinephrine and also displaying significant antagonism at muscarinic, histamine (H1), and alpha-adrenergic receptors[7][10][5]. This combination does not correspond to a known marketed pharmaceutical product or formulation, but collectively these agents may be used together in complex palliative care or off-label regimens.

02

Targets

DOR (Opioid Receptor Delta 1)mAChR (Muscarinic acetylcholine receptors)HRH1 (Histamine H1 Receptor)KOR (Kappa opioid receptor)SERT (Sodium-dependent serotonin transporter)ADRA1A (α1A)NET (Norepinephrine Transporter)MOR (Mu opioid receptor)BZD site (GABA-A receptor benzodiazepine site)

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