Drug intelligence / Profile preview

morphine + fentanyl

Development stage
Unknown
Lead developer
Janssen Pharmaceutica
Modality
Small Molecules
Administration
Intravenous, Epidural, Intrathecal, Subcutaneous, Intramuscular
01

Overview

Morphine + fentanyl is a combination of two opioid analgesics, morphine and fentanyl, used together for the management of severe pain, typically in surgical or critical care settings. Both drugs act as agonists at the mu-opioid receptor in the central nervous system, leading to potent analgesic effects. Morphine is a naturally occurring opiate derived from the opium poppy and has been widely used for pain relief. Fentanyl is a synthetic opioid that is 50–100 times more potent than morphine and provides rapid onset and short duration of action[1][2][4]. The combination may be employed when enhanced or synergistic pain control is required, but it carries an increased risk of respiratory depression and other opioid-related adverse effects due to their additive pharmacological actions.

Other names
intrathecal morphine with fentanylmorphine and fentanyl combination
02

Targets

KOR (Kappa opioid receptor)MOR (Mu opioid receptor)DOR (Opioid Receptor Delta 1)

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