morphine + normal saline

Morphine + normal saline refers to a specific analgesic regimen used in a clinical trial at Tel-Aviv Sourasky Medical Center for the management of postoperative pain. The protocol involves the epidural administration of morphine sulfate and normal saline at distinct time points (pre-incisional and post-incisional) to investigate the effects of preemptive analgesia in patients undergoing open colectomy. Morphine acts as a potent agonist of the mu-opioid receptor in the central nervous system, inhibiting ascending pain pathways and altering the perception of pain. This investigational use aims to optimize the timing of opioid administration to reduce overall postoperative pain scores and the consumption of supplemental analgesics like intravenous patient-controlled analgesia (IV-PCA) morphine. The normal saline component serves as a volume control or placebo in the crossover-style timing study.

Other names

epidural morphinemorphine sulfatenormal saline