morphine + saline

Morphine in saline is a standard analgesic formulation consisting of the mu-opioid receptor agonist morphine sulfate diluted in a 0.9% sodium chloride solution. In the context of a clinical trial conducted by the University of British Columbia (NCT01071057), this specific preparation (1 mg/mL) was utilized as the control arm to evaluate the efficacy of co-administered naloxone in preventing or treating opioid-induced pruritus in pediatric patients aged 8 to 18 years. Morphine provides potent analgesia for postoperative pain but is associated with a high incidence of pruritus, affecting up to 30% of children. The formulation is typically administered via intravenous patient-controlled analgesia (PCA) or continuous infusion, allowing for titrated pain relief while serving as a baseline for assessing the side-effect profile of opioids in a controlled clinical setting.

Other names

Saline/Morphinemorphine in normal salinemorphine sulfate in sodium chloride