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motexafin gadolinium + docetaxel
- Development stage
- Phase 1
- Lead developer
- Pharmacyclics
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Motexafin gadolinium + docetaxel is an investigational **combination regimen** consisting of motexafin gadolinium, a redox-active porphyrin-like compound, and docetaxel, a microtubule inhibitor. Motexafin gadolinium accumulates selectively in cancer cells and disrupts redox balance, inducing oxidative stress and apoptosis by generating reactive oxygen species and interfering with cellular antioxidant systems. Docetaxel binds to tubulin and promotes the assembly of microtubules while inhibiting their disassembly, blocking cell division and leading to cell death. The combination has been evaluated in clinical trials, primarily for advanced cancer including non-small cell lung cancer (NSCLC), based on preclinical evidence for synergistic antitumor effects and enhanced chemotherapy efficacy[1][2][4][8]. The primary developer for motexafin gadolinium is Pharmacyclics.
- Brand names
- Xcytrin (motexafin gadolinium)Taxotere (docetaxel)
- Other names
- MGd + docetaxel
02
Targets
PRDX5 (Peroxiredoxin-5)TUBB (Tubulin (alpha and beta subunits))RRM2TXNRD1 (Thioredoxin reductase 1)TXNRD2 (Thioredoxin reductase 2)
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