Drug intelligence / Profile preview

moxalactam (hydrolyzed)

Development stage
Unknown
Lead developer
Shionogi
Modality
Small Molecules
01

Overview

Moxalactam (hydrolyzed) is the hydrolyzed form of moxalactam, a synthetic oxa-beta-lactam antibiotic belonging to the beta-lactam class. Moxalactam itself acts by inhibiting bacterial cell wall biosynthesis, targeting penicillin-binding proteins and thereby preventing peptidoglycan cross-linking in bacterial cell walls. The hydrolyzed form refers to its chemical breakdown product, which confers resistance to various beta-lactams via hydrolysis of the beta-lactam ring[1][4]. Moxalactam is notable for its broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Enterobacteriaceae and Bacteroides fragilis; it is resistant to many beta-lactamases[2][3]. However, the hydrolyzed form does not have clinical use as an antibiotic but may be relevant in studies of resistance mechanisms or drug metabolism.

02

Targets

MBL (Class B metallo-beta-lactamase)CD200

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