Drug intelligence / Profile preview

moxifloxacin + ketorolac

Development stage
Unknown
Lead developer
Akrovis
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Mofdrib-KT Eye Drops is a fixed-dose combination ophthalmic solution developed by Akrovis Pharmaceuticals. It contains moxifloxacin, a fourth-generation fluoroquinolone antibiotic, and ketorolac tromethamine, a non-steroidal anti-inflammatory drug (NSAID). The product is indicated for the treatment of bacterial ocular infections where an anti-inflammatory component is also required, such as in the management of post-operative inflammation following cataract surgery or in cases of bacterial conjunctivitis with significant swelling and pain. Moxifloxacin provides broad-spectrum antibacterial activity by inhibiting DNA gyrase and topoisomerase IV, while ketorolac reduces ocular pain and inflammation by inhibiting prostaglandin synthesis through the blockade of cyclooxygenase enzymes.

Brand names
Mofdrib-KT Eye Drops
Other names
Mofdrib-KTmoxifloxacin + ketorolac tromethamine
02

Targets

Topo IV (Bacterial Topoisomerase IV)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)DNA gyrase

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