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Drug intelligence / Profile preview
mRNA-2752 + pembrolizumab
- Development stage
- Phase 1
- Lead developer
- Moderna
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intratumoral
01
Overview
mRNA-2752 + pembrolizumab is a combination therapy consisting of intratumoral injections of pembrolizumab (an immune checkpoint inhibitor) and mRNA-2752 (a lipid nanoparticle encoding three immunostimulatory proteins: OX40L, IL-23, and IL-36γ). This combination is designed to enhance anti-tumor immune responses by simultaneously blocking immune checkpoints and stimulating pro-inflammatory pathways within the tumor microenvironment. The therapy has shown promising results in high-risk ductal carcinoma in situ (DCIS), particularly in HER2-positive or hormone receptor-negative disease, with evidence of rapid tumor regression and immune infiltration.
02
Targets
IL23R (Interleukin-23 Receptor)IL1RL2 (Interleukin 36 Receptor)CD28 (Cluster of Differentiation 28)PDCD1 (Programmed cell death protein 1 receptor)IL-23 (Interleukin-23)IL36G (IL-36γ)TNFSF4 (Tumor necrosis factor ligand superfamily member 4)
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