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mSAR'877
- Development stage
- Preclinical
- Lead developer
- Sanofi
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Cytokines & Interferons → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
mSAR'877 is a murine surrogate of SAR445877, a novel antibody-cytokine fusion protein developed by Sanofi. It consists of a murine anti-PD-1 antibody fused to a mutated murine interleukin-15 (IL-15) and IL-15 receptor alpha sushi domain. The molecule is designed to cis-activate effector T cells by biasing IL-15 stimulation specifically to T cells expressing PD-1, thereby enhancing anti-tumor activity while potentially reducing systemic toxicities associated with untargeted IL-15. In preclinical B16-OVA mouse models, mSAR'877 has demonstrated superior efficacy compared to anti-PD-1 monotherapy or untargeted IL-15, characterized by increased tumor immune cell infiltration (CD8+ T cells and NK cells) and tumor regression.
- Other names
- murine surrogate anti-mPD-1-mutmIL15
02
Targets
IL15 (Interleukin 15)PDCD1 (Programmed cell death protein 1 receptor)IL15RA (Interleukin-15 receptor subunit alpha)
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