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Mtb72F + AS02A
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
A combination **vaccine candidate** comprising the recombinant fusion protein **Mtb72F**—a polyprotein derived from the antigens Mtb32 and Mtb39 of Mycobacterium tuberculosis—**formulated with the adjuvant AS02A**. Designed as an adjunct to Bacillus Calmette–Guérin (BCG) vaccination, the combination aims to induce a strong and long-lasting Th1-type immune response (increased IFN-γ, TNF-α, IL-2) to enhance protection against tuberculosis. In nonhuman primates and guinea pig models, Mtb72F + AS02A improved survival and promoted lesion resolution compared to BCG alone. Mtb72F/AS02A can serve as a booster following BCG vaccination and is under evaluation as a tuberculosis vaccine strategy[1][2].
- Other names
- Mtb72F + AS02AMtb72F/AS02AMtb72F-AS02AMtb-72F-AS02AMtb 72F-AS02A
02
Targets
MHC II (Major histocompatibility complex class II receptor)TCR-Mtb32A/Mtb39A (T-cell receptor specific for Mycobacterium tuberculosis Mtb32A and Mtb39A epitopes)TLR4 (Toll-like receptor 4)T-cell receptor specific for Mycobacterium tuberculosis Mtb32A and Mtb39A antigensMHC I (MHC class I})
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