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MVA + HIVA
- Development stage
- Phase 2
- Lead developer
- University of Oxford
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
MVA + HIVA is a combination vaccine candidate for HIV that utilizes the Modified Vaccinia Ankara (MVA) viral vector to deliver the synthetic "HIVA" immunogen. The "HIVA" component is a chimeric gene encoding conserved regions of the human immunodeficiency virus type 1 (HIV-1), designed to induce robust and broad T-cell immune responses against HIV. The vaccine aims to stimulate both CD4+ and CD8+ T cell responses targeting multiple epitopes of the virus, with potential applications in both preventive and therapeutic settings for HIV infection. The approach leverages the safety profile of non-replicating MVA vectors and their ability to induce strong cellular immunity.
- Other names
- Modified Vaccinia Ankara expressing HIVA immunogenMVA-HIVA
02
Targets
HIV-1 antigens
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