mycophenolate acid + azathioprine

Mycophenolate acid (commonly administered as its prodrug, mycophenolate mofetil) and azathioprine are both immunosuppressive agents that inhibit purine synthesis, thereby reducing DNA and RNA production required for lymphocyte proliferation. Mycophenolate selectively inhibits inosine monophosphate dehydrogenase (IMPDH), leading to decreased guanosine nucleotide synthesis in T and B lymphocytes. Azathioprine is converted to 6-mercaptopurine, which is further metabolized into active thioguanine nucleotides that disrupt DNA replication and induce apoptosis in immune cells. Both drugs are primarily used to prevent organ transplant rejection and treat autoimmune diseases such as systemic lupus erythematosus and lupus nephritis[1][4][6]. Coadministration of these agents is generally avoided due to overlapping mechanisms of action and increased risk of adverse effects[5].

Brand names

CellCept

Other names

mycophenolic acidMMF6-mercaptopurine prodrug