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N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]-4-methoxybenzohydrazide
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]-4-methoxybenzohydrazide is a synthetic small molecule belonging to the hydrazide class. It features a dibrominated dihydroxyphenyl moiety linked via a hydrazone bond to a methoxy-substituted benzoyl group. The compound has been studied as an inhibitor of bacterial fatty acid biosynthesis by targeting the enzyme 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ in Helicobacter pylori. This enzyme is involved in unsaturated fatty acid biosynthesis and catalyzes dehydration steps essential for bacterial membrane formation[2]. The compound is primarily used in research settings and has not been approved for clinical use.
- Other names
- N'-[(E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]-4-methoxybenzohydrazideBenzoic acid 4-methoxy-, 2-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
02
Targets
FabZ (3-hydroxyacyl-ACP dehydratase FabZ)
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