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Nα-[(2S)-2-{[(S)-[(1S)-1-{[(Benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]methyl}-5-phenylpentanoyl]-L-tryptophanamide
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
Nα‑[(2S)‑2‑{[(S)‑[(1S)‑1‑{[(Benzyloxy)carbonyl]amino}‑2‑phenylethyl](hydroxy)phosphoryl]methyl}‑5‑phenylpentanoyl]–L–tryptophanamide is a synthetic small molecule belonging to the class of n-acyl-alpha amino acids and derivatives[1][3]. It is an experimental compound, not approved for clinical use, and has been studied primarily as a research tool. The molecule features a benzyloxycarbonyl-protected amino group, phenylethyl and tryptophan moieties, and a hydroxyphosphinyl group. While its precise mechanism of action in humans is not fully characterized in public sources, it has structural similarity to retro-thiorphan analogues that are known inhibitors of certain metalloproteases such as neutral endopeptidase (NEP), suggesting potential activity as an enzyme inhibitor[8]. No clinical indications or advanced development status are reported.
- Other names
- Nalpha-[(2S)-2-{[(S)-[(1S)-1-{[(Benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]methyl}-5-phenylpentanoyl]-L-tryptophanamide(R)-RETRO-THIORPHAN1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-indol-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID
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