N-(1-cyanocyclopropyl)-3-({[(2S)-5-oxopyrrolidin-2-yl]methyl}sulfonyl)-N~2~-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alaninamide

This compound is a synthetic small molecule belonging to the class of alpha amino acid amides. It is an experimental drug and functions as a covalent inhibitor of cathepsin S—a cysteine protease involved in antigen presentation and immune system regulation. The molecule contains a nitrile warhead that forms a covalent bond with the active site cysteine residue of cathepsin S. Its primary use has been in structural biology studies to understand enzyme inhibition mechanisms and for drug design targeting papain-like cysteine proteases such as cathepsin S[5][7]. There are no known approved therapeutic indications or marketed formulations for this compound.

Other names

N-(1-cyanocyclopropyl)-3-({[(2S)-5-oxopyrrolidin-2-yl]methyl}sulfonyl)-N~2~-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alaninamide(2R)-N-(1-cyanocyclopropyl)-3-{[(2S)-5-oxopyrrolidin-2-yl]methanesulfonyl}-2-{[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino}propanamide[2]