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n-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
01
Overview
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-Fluorobenzamide is a small molecule inhibitor belonging to the class of N-(3-Cyano-benzo[b]thienyl)amides. This compound is structurally related to a series of potent and selective inhibitors of JNK (c-Jun N-terminal kinase) kinases. While the specific activity profile for this exact compound has not been published in detail in major journals or databases as a clinical candidate or marketed drug (unlike some close analogs), it shares structural and mechanistic features with compounds that are known to inhibit JNK isoforms such as JNK2 and JNK3[1][4]. These inhibitors typically act by binding to the ATP-binding site of the kinase domain.
- Other names
- N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-fluorobenzamideN-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-Fluorobenzamide
02
Targets
JNK (Mitogen-activated protein kinase kinase kinase family)
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