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N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(4-bromo-2,5-dimethoxyphenyl)acetamide

Development stage: Unknown
Modality: Small Molecules

Overview

N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(4-bromo-2,5-dimethoxyphenyl)acetamide is an experimental small molecule inhibitor. It is not approved for clinical use and has no known brand names or marketed indications. The compound acts as a potent inhibitor of mitogen‑activated protein kinase 8 (MAPK8, also known as JNK1), with an IC50 of 77 nM reported in biochemical assays[2]. Its primary mechanism involves targeting the MAPK8 enzyme, which plays a role in cellular signaling pathways related to inflammation and apoptosis. No developer or manufacturer information is available; it appears to be used primarily in research settings.

Other names: N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE

Targets

JNK (Mitogen-activated protein kinase kinase kinase family)

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