N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide

N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide is an experimental small molecule belonging to the alpha amino acid amide class. It is a synthetic compound designed as a selective inhibitor of prothrombin, specifically targeting thrombin activity. Thrombin is a serine protease that plays a central role in the coagulation cascade by converting fibrinogen to fibrin and activating several other coagulation factors. Structural and biochemical studies have shown that this compound binds to thrombin, inhibiting its enzymatic activity through interactions involving both hydrophobic contacts and hydrogen bonding within the active site[1][8]. The drug has been studied primarily in academic settings for its potential as an anticoagulant or antithrombotic agent, but there are no indications of clinical development or commercial use.

Other names

(2S)-N-[(4-carbamimidoylphenyl)methyl]-1-(3-phenylpropanoyl)pyrrolidine-2-carboxamide(2S)-N-((4-carbamimidoylphenyl)methyl)-1-(3-phenylpropanoyl)pyrrolidine-2-carboxamide