N-(quinolin-8-yl)methanesulfonamide

N-(quinolin-8-yl)methanesulfonamide is a synthetic small molecule belonging to the sulfonamide class, characterized by a quinoline moiety linked to a methanesulfonamide group. It has been studied primarily as an experimental compound in medicinal chemistry and chemical biology. The compound exhibits potential antimicrobial activity and has been explored for its ability to act as a bidentate ligand, coordinating with metal ions via the sulfonamide nitrogen and quinoline nitrogen atoms. In pharmacophore libraries, it has shown promise in targeting enzymes such as Glyoxalase 1 (GLO1), suggesting possible roles in modulating metal-binding interactions relevant to oncology and antimicrobial research[3][6]. However, there are no approved indications or clinical trials beyond preclinical investigation[1][10].

Other names

8-(methylsulfonylamino)quinolineN-quinolin-8-ylmethanesulfonamideN-quinolin8-ylmethanesulfonamideN-quinolin 8-ylmethanesulfonamideN-(8-chinolinyl)methansulfonamidN-(8-qunolinyl)methanesulfonamideMethanesulfonamide, N–8–quinolinyl–CAS 10374–76–2